Mouse Mmp24 activation kit by CRISPRa

SKU GA202682

Mmp24 CRISPRa kit - CRISPR gene activation of mouse matrix metallopeptidase 24

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: Mmp24
• Locus ID: 17391
• Components:

  GA202682G1, Mmp24 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA202682G2, Mmp24 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA202682G3, Mmp24 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_010808
• UniProt ID: Q9R0S2
• Synonyms: AU040325; MMP-21; MT5-MMP; MT5MMP; MTMMP5
• Summary: This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme. Mice lacking the encoded protein do not develop neuropathic pain with mechanical allodynia after sciatic nerve injury, display enhanced sensitivity to noxious thermal stimuli under basal conditions, and develop hyperalgesia during inflammation. [provided by RefSeq, Feb 2016]