Mouse Mmp10 activation kit by CRISPRa

SKU GA202675

Mmp10 CRISPRa kit - CRISPR gene activation of mouse matrix metallopeptidase 10

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: Mmp10
• Locus ID: 17384
• Components:

  GA202675G1, Mmp10 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA202675G2, Mmp10 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA202675G3, Mmp10 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_019471
• UniProt ID: O55123
• Synonyms: AV377895; MMP-10; SL-2
• Summary: This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme. The lack of encoded protein in mice promotes experimental lung cancer formation, exacerbates experimental colitis and promotes development of inflammation-associated colonic dysplasia. This gene is located in a cluster of other matrix metalloproteinase genes on chromosome 9. [provided by RefSeq, Feb 2016]