Mouse Mef2c activation kit by CRISPRa

SKU GA202630

Mef2c CRISPRa kit - CRISPR gene activation of mouse myocyte enhancer factor 2C

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: Mef2c
• Locus ID: 17260
• Components:

  GA202630G1, Mef2c gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA202630G2, Mef2c gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA202630G3, Mef2c gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001170537, NM_001347564, NM_001347566, NM_001347567, NM_001347568, NM_001347569, NM_001347571, NM_001347572, NM_001347573, NM_001347574, NM_001347575, NM_001347576, NM_001347577, NM_001347578, NM_001347579, NM_001347580, NM_001347581, NM_025282
• UniProt ID: Q8CFN5
• Synonyms: 5430401D19Rik; 9930028G15Rik; AV011172; Mef2
• Summary: Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18 (PubMed:11554755). May also be involved in neurogenesis and in the development of cortical architecture. Isoforms that lack the repressor domain are more active than isoform 1 (By similarity). Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells.[UniProtKB/Swiss-Prot Function]