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Mouse Smad4 activation kit by CRISPRa

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SKU
GA202547
Smad4 CRISPRa kit - CRISPR gene activation of mouse SMAD family member 4
  $1,657.00
4 Weeks*

Frequently Bought Together (1)

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100 ug
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Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol Smad4
Locus ID 17128
Components

GA202547G1, Smad4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA202547G2, Smad4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA202547G3, Smad4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Shipping Ambient
Reference Data
RefSeq NM_008540, NM_001364967, NM_001364968
UniProt ID P97471
Synonyms AW743858; D18Wsu70e; DPC4; Madh4
Summary Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in response to TGF-beta. May act as a tumor suppressor. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (By similarity). Acts synergistically with SMAD1 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (PubMed:15329343). Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions (PubMed:15329343). In muscle physiology, plays a central role in the balance between atrophy and hypertrophy. When recruited by MSTN, promotes atrophy response via phosphorylated SMAD2/4. MSTN decrease causes SMAD4 release and subsequent recruitment by the BMP pathway to promote hypertrophy via phosphorylated SMAD1/5/8.UniProtKB/Swiss-Prot Function
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Documents
Resources
Other Versions
SKU Description Size Price
KN316273 Smad4 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN316273BN Smad4 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN316273LP Smad4 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN316273RB Smad4 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN516273 Smad4 - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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