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Mouse Smad3 activation kit by CRISPRa

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SKU
GA202546
Smad3 CRISPRa kit - CRISPR gene activation of mouse SMAD family member 3
  $1,657.00
4 Weeks*

Other products for "Smad3"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol Smad3
Locus ID 17127
Components

GA202546G1, Smad3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA202546G2, Smad3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA202546G3, Smad3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Shipping Ambient
Reference Data
RefSeq NM_016769
UniProt ID Q8BUN5
Synonyms AU022421; Madh3
Summary Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (By similarity).UniProtKB/Swiss-Prot Function
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Documents
Resources
Other Versions
SKU Description Size Price
KN316272 Smad3 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN316272BN Smad3 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN316272LP Smad3 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN316272RB Smad3 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN516272 Smad3 - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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