Mouse Lox activation kit by CRISPRa

SKU GA202483

Lox CRISPRa kit - CRISPR gene activation of mouse lysyl oxidase

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: Lox
• Locus ID: 16948
• Components:

  GA202483G1, Lox gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA202483G2, Lox gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA202483G3, Lox gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001286181, NM_001286182, NM_010728
• UniProt ID: P28301
• Synonyms: AI893619; rrg; TSC-160
• Summary: This gene encodes a precursor protein that belongs to the lysyl oxidase family of proteins. The secreted proprotein is proteolytically processed to an active mature peptide and a propeptide. This propeptide is thought to function in tumor suppression by inhibiting the Ras signaling pathway. The active enzyme plays a role in cross-linking of collagen and elastin and is essential for development of cardiovascular and respiratory systems, and development of skin and connective tissue. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013]