Mouse Ldhb activation kit by CRISPRa

SKU GA202432

Ldhb CRISPRa kit - CRISPR gene activation of mouse lactate dehydrogenase B

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: Ldhb
• Locus ID: 16832
• Components:

  GA202432G1, Ldhb gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA202432G2, Ldhb gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA202432G3, Ldhb gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001302765, NM_008492
• UniProt ID: P16125
• Synonyms: AI790582; H-Ldh; Ldh-2; LDH-B; LDH-H; Ldh2
• Summary: This gene encodes the B subunit of lactate dehydrogenase enzyme, which catalyzes the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD+ in a post-glycolysis process. Alternatively spliced transcript variants have also been found for this gene. Recent studies have shown that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is localized in the peroxisomes. Pseudogenes have been identified on chromosomes 1 and 19. [provided by RefSeq, Feb 2016]