Mouse Irf4 activation kit by CRISPRa

SKU GA202182

Irf4 CRISPRa kit - CRISPR gene activation of mouse interferon regulatory factor 4

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: Irf4
• Locus ID: 16364
• Components:

  GA202182G1, Irf4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA202182G2, Irf4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA202182G3, Irf4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001347508, NM_013674
• UniProt ID: Q64287
• Synonyms: AI385587; IRF-4; LSIRF; NF-EM5; Spip
• Summary: Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes.[UniProtKB/Swiss-Prot Function]