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Mouse Il10ra activation kit by CRISPRa

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SKU
GA202113
Il10ra CRISPRa kit - CRISPR gene activation of mouse interleukin 10 receptor, alpha
  $1,657.00
4 Weeks*

Frequently Bought Together (1)

TA386342 Recombinant Anti-IL-10R (Clone 1B1.3a)
200 ug
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Other products for "Il10ra"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol Il10ra
Locus ID 16154
Components

GA202113G1, Il10ra gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA202113G2, Il10ra gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA202113G3, Il10ra gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_001324486, NM_008348, NR_136903
UniProt ID Q61727
Synonyms AW553859; CDw210; CDw210a; IL-10R1; IL-10RA; Il10r; mIL-10R
Summary Cell surface receptor for the cytokine IL10 that participates in IL10-mediated anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Upon binding to IL10, induces a conformational change in IL10RB, allowing IL10RB to bind IL10 as well. In turn, the heterotetrameric assembly complex, composed of two subunits of IL10RA and IL10RB, activates the kinases JAK1 and TYK2 that are constitutively associated with IL10RA and IL10RB respectively. These kinases then phosphorylate specific tyrosine residues in the intracellular domain in IL10RA leading to the recruitment and subsequent phosphorylation of STAT3 (PubMed:8910398). Once phosphorylated, STAT3 homodimerizes, translocates to the nucleus and activates the expression of anti-inflammatory genes. In addition, IL10RA-mediated activation of STAT3 inhibits starvation-induced autophagy (By similarity).UniProtKB/Swiss-Prot Function
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Other Versions
SKU Description Size Price
KN508219 Il10ra - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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