Mouse Ifit2 activation kit by CRISPRa

SKU GA202069

Ifit2 CRISPRa kit - CRISPR gene activation of mouse interferon-induced protein with tetratricopeptide repeats 2

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: Ifit2
• Locus ID: 15958
• Components:

  GA202069G1, Ifit2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA202069G2, Ifit2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA202069G3, Ifit2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_008332, NM_001355262
• UniProt ID: Q64112
• Synonyms: AV302338; Ifi54; P54
• Summary: IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5' triphosphorylation, RNA-binding is required for antiviral activity. Can promote apoptosis.[UniProtKB/Swiss-Prot Function]