Mouse Mr1 activation kit by CRISPRa

SKU GA201833

Mr1 CRISPRa kit - CRISPR gene activation of mouse major histocompatibility complex, class I-related

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: Mr1
• Locus ID: 15064
• Components:

  GA201833G1, Mr1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA201833G2, Mr1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA201833G3, Mr1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_008209, NM_001355062, NM_001355063
• UniProt ID: Q8HWB0
• Synonyms: H2ls
• Summary: Antigen-presenting molecule specialized in presenting microbial vitamin B metabolites (By similarity). Involved in the development and expansion of a small population of T-cells expressing an invariant T-cell receptor alpha chain called mucosal-associated invariant T-cells (MAIT). MAIT lymphocytes are preferentially located in the gut lamina propria and therefore may be involved in monitoring commensal flora or serve as a distress signal. Expression and MAIT cell recognition seem to be ligand-dependent.[UniProtKB/Swiss-Prot Function]