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Mouse Gabrb3 activation kit by CRISPRa

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SKU
GA201520
Gabrb3 CRISPRa kit - CRISPR gene activation of mouse gamma-aminobutyric acid (GABA) A receptor, subunit beta 3
  $1,657.00
4 Weeks*

Other products for "Gabrb3"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol Gabrb3
Locus ID 14402
Components

GA201520G1, Gabrb3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA201520G2, Gabrb3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA201520G3, Gabrb3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Shipping Ambient
Reference Data
RefSeq NM_001038701, NM_008071
UniProt ID P63080
Synonyms A230092K12Rik; AW049585; beta3; Cp1; Gabrb-3
Summary Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed:9108119). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA- gated ion channel (PubMed:27129275). The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (PubMed:27129275). The alpha1/beta3/gamma2 receptor exhibits synatogenic activity whereas the alpha2/beta3/gamma2 receptor shows very little or no synaptogenic activity (PubMed:27129275). Functions also as histamine receptor and mediates cellular responses to histamine (By similarity). Plays an important role in somatosensation and in the production of antinociception (PubMed:10670447).UniProtKB/Swiss-Prot Function
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Other Versions
SKU Description Size Price
KN506244 Gabrb3 - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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