Mouse Lpin1 activation kit by CRISPRa

SKU GA201442

Lpin1 CRISPRa kit - CRISPR gene activation of mouse lipin 1

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: Lpin1
• Locus ID: 14245
• Components:

  GA201442G1, Lpin1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA201442G2, Lpin1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA201442G3, Lpin1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001130412, NM_015763, NM_172950, NM_001355598
• UniProt ID: Q91ZP3
• Synonyms: 4631420P06; fld; Kiaa0188; Lipin1; mKIAA0188
• Summary: Plays important roles in controlling the metabolism of fatty acids at different levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis. Acts also as nuclear transcriptional coactivator for PPARGC1A/PPARA regulatory pathway to modulate lipid metabolism gene expression. Is involved in adipocyte differentiation. Isoform 1 is recruited at the mitochondrion outer membrane and is involved in mitochondrial fission by converting phosphatidic acid to diacylglycerol.[UniProtKB/Swiss-Prot Function]