Mouse Cdkn2a activation kit by CRISPRa

SKU GA200679

Cdkn2a CRISPRa kit - CRISPR gene activation of mouse cyclin dependent kinase inhibitor 2A

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: Cdkn2a
• Locus ID: 12578
• Components:

  GA200679G1, Cdkn2a gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA200679G2, Cdkn2a gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA200679G3, Cdkn2a gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001040654, NM_009877
• UniProt ID: Q64364
• Synonyms: Arf; ARF-INK4a; INK4a-ARF; Ink4a/Arf; MTS1; p16; p16(INK4a); p16INK4a; p19<ARF>; p19ARF; Pctr1
• Summary: Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein.[UniProtKB/Swiss-Prot Function]