Mouse Ctnnb1 activation kit by CRISPRa
SKU
GA200548
Ctnnb1 CRISPRa kit - CRISPR gene activation of mouse catenin (cadherin associated protein), beta 1
$1,657.00
4 Weeks*
Specifications
| Product Data | |
| Format | 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug) |
|---|---|
| Target Symbol | Ctnnb1 |
| Locus ID | 12387 |
| Components |
GA200548G1, Ctnnb1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA200548G2, Ctnnb1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA200548G3, Ctnnb1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077 |
| OTI Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_001165902, NM_007614 |
| UniProt ID | Q02248 |
| Synonyms | Bfc; Catnb; Mesc |
| Summary | This gene encodes not only an important cytoplasmic component of the classical cadherin adhesion complex that forms the adherens junction in epithelia and mediates cell-cell adhesion in many other tissues but also a key signaling molecule in the canonical Wnt signaling pathway that controls cell growth and differentiation during both normal development and tumorigenesis. The gene product contains a central armadillo-repeat containing domain through which it binds the cytoplasmic tail of classical cadherins; meanwhile, it also binds alpha-catenin, which further links the cadherin complex to the actin cytoskeleton either directly or indirectly. Beta-catenin is therefore necessary for the adhesive function of classical cadherins. Another key function of this protein is to mediate the canonical Wnt signaling pathway and regulate gene transcription. Without Wnt signal, cytoplasmic beta-catenin that is not associated with the cadherin complex is quickly phosphorylated at the N-terminal Ser/Thr residues by the so called degradation complex containing axin, adenomatous polyposis coli (APC), casein kinase I, and GSK3B, then ubiquitylated by beta-TrCP, and degraded by the proteasome. However, in the presence of Wnt signal, the degradation complex is disrupted and the stabilized cytoplasmic beta-catenin translocates into the nucleus, where it binds various transcription factors and, together with these factors, regulates the transcription of many downstream genes. Mutations of this gene have been linked with various types of tumors. Alternatively spliced variants have been found for this gene. provided by RefSeq, Sep 2009 |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
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| KN303967 | Ctnnb1 - mouse gene knockout kit via CRISPR, HDR mediated | 1 kit |
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| KN303967BN | Ctnnb1 - mouse gene knockout kit via CRISPR, HDR mediated | 1 kit |
$1,657.00
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| KN303967LP | Ctnnb1 - mouse gene knockout kit via CRISPR, HDR mediated | 1 kit |
$1,657.00
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| KN303967RB | Ctnnb1 - mouse gene knockout kit via CRISPR, HDR mediated | 1 kit |
$1,657.00
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| KN503967 | Ctnnb1 - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. | 1 kit |
$1,657.00
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Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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