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Mouse Cacna1c activation kit by CRISPRa

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SKU
GA200477
Cacna1c CRISPRa kit - CRISPR gene activation of mouse calcium channel, voltage-dependent, L type, alpha 1C subunit
  $1,657.00
4 Weeks*

Other products for "Cacna1c"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol Cacna1c
Locus ID 12288
Components

GA200477G1, Cacna1c gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA200477G2, Cacna1c gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA200477G3, Cacna1c gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Shipping Ambient
Reference Data
RefSeq NM_001159533, NM_001159534, NM_001159535, NM_001255997, NM_001255998, NM_001255999, NM_001256000, NM_001256001, NM_001256002, NM_001290335, NM_009781
UniProt ID Q01815
Synonyms Cav1.2; Cchl1a1; D930026N18Rik; MBC; MELC-CC
Summary Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PubMed:14609949, PubMed:18586882, PubMed:21216955, PubMed:25368181, PubMed:28119464). Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm (By similarity). Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm (PubMed:21216955). Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells (PubMed:14609949, PubMed:28119464). Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group (Probable).UniProtKB/Swiss-Prot Function
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Documents
Resources
Other Versions
SKU Description Size Price
KN502415 Cacna1c - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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