Mouse Bdnf activation kit by CRISPRa

SKU GA200395

Bdnf CRISPRa kit - CRISPR gene activation of mouse brain derived neurotrophic factor

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: Bdnf
• Locus ID: 12064
• Components:

  GA200395G1, Bdnf gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA200395G2, Bdnf gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA200395G3, Bdnf gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001048139, NM_001048141, NM_001048142, NM_001285416, NM_001285417, NM_001285418, NM_001285419, NM_001285420, NM_001285421, NM_001285422, NM_007540
• UniProt ID: P21237
• Summary: The protein encoded by this gene is a member of the nerve growth factor family. It is involved in the growth, differentiation and survival of specific types of developing neurons both in the central nervous system (CNS) and the peripheral nervous system. It is also involved in regulating synaptic plasticity in the CNS. Expression of a similar gene in human is reduced in both Alzheimer's and Huntington disease patients. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Oct 2015]