Mouse Aqp4 activation kit by CRISPRa

SKU
GA200253
Aqp4 CRISPRa kit - CRISPR gene activation of mouse aquaporin 4
  $1,657.00
4 Weeks*
Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol Aqp4
Locus ID 11829
Components

GA200253G1, Aqp4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA200253G2, Aqp4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA200253G3, Aqp4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077

OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Shipping Ambient
Reference Data
RefSeq NM_009700
UniProt ID P55088
Synonyms WCH4
Summary This gene encodes a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. This protein is the predominant aquaporin found in brain and has an important role in brain water homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. provided by RefSeq, Dec 2015
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Documents
Resources
Other Versions
SKU Description Size Price
KN501453 Aqp4 - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

file-alt Citations

Curcumin alleviates brain edema by lowering AQP4 expression levels in a rat model of hypoxia-hypercapnia-induced brain damage
Yu, Fan, Ye et al
Exp Ther Med (2016) 11 (3), 709-716 DOI: 10.3892/etm.2016.3022
Cited by 32
AI Summary: OriGene products contributed to this study by providing the AQP4 antibody (Cat# TA336295) and AQP4 primers (Cat# HQP019363), which were used to detect AQP4 protein and mRNA expression levels in rat brain tissues.
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Showing 1-1 of 1 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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