Mouse Apaf1 activation kit by CRISPRa

SKU GA200220

Apaf1 CRISPRa kit - CRISPR gene activation of mouse apoptotic peptidase activating factor 1

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: Apaf1
• Locus ID: 11783
• Components:

  GA200220G1, Apaf1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA200220G2, Apaf1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA200220G3, Apaf1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001042558, NM_001282947, NM_009684
• UniProt ID: O88879
• Synonyms: 6230400I06Rik; Apaf-1; Apaf1l; fog; mKIAA0413
• Summary: Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP (By similarity).[UniProtKB/Swiss-Prot Function]