Mouse Prdx6 activation kit by CRISPRa

SKU GA200201

Prdx6 CRISPRa kit - CRISPR gene activation of mouse peroxiredoxin 6

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: Prdx6
• Locus ID: 11758
• Components:

  GA200201G1, Prdx6 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA200201G2, Prdx6 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA200201G3, Prdx6 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001303408, NM_007453, NR_130150
• UniProt ID: O08709
• Synonyms: 1-Cys Prx; 1-cysPrx; 9430088D19Rik; AA690119; aiPLA2; Aop2; Brp-12; CP-3; GPx; Ltw-4; Ltw4
• Summary: This gene encodes a member of the peroxiredoxin family of peroxidases. The encoded protein is a bifunctional enzyme that has glutathione peroxidase and phospholipase activities. This protein is an antioxidant that reduces peroxidized membrane phospholipids and plays an important role in phospholipid homeostasis based on its ability to generate lysophospholipid substrate for the remodeling pathway of phospholipid synthesis. Mice lacking this gene are sensitive to oxidant stress, have altered lung phospholipid metabolism and susceptible to skin tumorigenesis. Alternate splicing of this gene results in multiple transcript variants. A pseudogene of this gene is found on chromosome 4. [provided by RefSeq, Dec 2014]