Human LYPD8 activation kit by CRISPRa

SKU GA118782

LYPD8 CRISPRa kit - CRISPR gene activation of human LY6/PLAUR domain containing 8

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: LYPD8
• Locus ID: 646627
• Components:

  GA118782G1, LYPD8 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA118782G2, LYPD8 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA118782G3, LYPD8 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001085474, NM_001291283
• UniProt ID: Q6UX82
• Summary: Secreted protein specifically required to prevent invasion of Gram-negative bacteria in the inner mucus layer of the colon epithelium, a portion of the large intestine which is free of commensal microbiota. Prevents invasion of flagellated microbiota by binding to the flagellum of bacteria, such as P.mirabilis, thereby inhibiting bacterial motility in the intestinal lumen. Segregation of intestinal bacteria and epithelial cells in the colon is required to preserve intestinal homeostasis.[UniProtKB/Swiss-Prot Function]