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Human KIR2DL5B activation kit by CRISPRa

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SKU
GA118626
KIR2DL5B CRISPRa kit - CRISPR gene activation of human killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 5B
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA338338 Rabbit Polyclonal Anti-KIR2DL5B Antibody
100 ul
$585.00
RC213765 KIR2DL5B (Myc-DDK-tagged)-Human killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5B (KIR2DL5B)
10 ug
$686.00

Other products for "KIR2DL5B"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol KIR2DL5B
Locus ID 553128
Components

GA118626G1, KIR2DL5B gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA118626G2, KIR2DL5B gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA118626G3, KIR2DL5B gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_001018081
Synonyms KIR2DL5; KIR2DL5.2; KIR2DLX
Summary Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. provided by RefSeq, Jul 2008
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Documents
Resources
Other Versions
SKU Description Size Price
KN413765 KIR2DL5B - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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