Human GCN2 (EIF2AK4) activation kit by CRISPRa

SKU GA118447

EIF2AK4 CRISPRa kit - CRISPR gene activation of human eukaryotic translation initiation factor 2 alpha kinase 4

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: EIF2AK4
• Locus ID: 440275
• Components:

  GA118447G1, GCN2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA118447G2, GCN2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA118447G3, GCN2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001013703
• UniProt ID: Q9P2K8
• Synonyms: GCN2; PVOD2
• Summary: This gene encodes a member of a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2), resulting in the downregulaton of protein synthesis. The encoded protein responds to amino acid deprivation by binding uncharged transfer RNAs. It may also be activated by glucose deprivation and viral infection. Mutations in this gene have been found in individuals suffering from autosomal recessive pulmonary venoocclusive-disease-2. [provided by RefSeq, Mar 2014]