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Human VHLL activation kit by CRISPRa

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SKU
GA118195
VHLL CRISPRa kit - CRISPR gene activation of human VHL like
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA330819 Rabbit Polyclonal Anti-VHLL Antibody
100 ul
$585.00
RC219675 VHLL (Myc-DDK-tagged)-Human von Hippel-Lindau tumor suppressor-like (VHLL)
10 ug
$150.00

Other products for "VHLL"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol VHLL
Locus ID 391104
Components

GA118195G1, VHLL gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA118195G2, VHLL gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA118195G3, VHLL gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_001004319
UniProt ID Q6RSH7
Synonyms VHLP; VLP
Summary Von Hippel-Lindau (VHL) tumor suppressor protein is a component of an E3 ubiquitin ligase complex that selectively ubiquitinates the alpha subunit of the hypoxia-inducible factor (HIF) transcription factor for proteasome-mediated degradation. Inactivation of VHL causes VHL disease and sporadic kidney cancer. This gene encodes a VHL homolog that lacks one of two key domains necessary for VHL function. This gene may contribute to the regulation of oxygen homeostasis and neovascularization during placenta development. This gene is intronless, and can also be interpreted as a retrotransposed pseudogene of the VHL locus located on chromosome 3. However, the protein is represented in this RefSeq due to evidence in PMID:14757845 that strongly suggests it is translated. The same publication also indicates that this protein binds HIF alpha but fails to recruit the E3 ubiquitin ligase complex, and it therefore functions as a dominant-negative VHL protein and a protector of HIF alpha. provided by RefSeq, Jan 2010
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Documents
Resources
Other Versions
SKU Description Size Price
KN419675 VHLL - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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