Human NHLRC1 activation kit by CRISPRa

SKU GA117849

NHLRC1 CRISPRa kit - CRISPR gene activation of human NHL repeat containing E3 ubiquitin protein ligase 1

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: NHLRC1
• Locus ID: 378884
• Components:

  GA117849G1, NHLRC1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA117849G2, NHLRC1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA117849G3, NHLRC1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_198586
• UniProt ID: Q6VVB1
• Synonyms: bA204B7.2; EPM2A; EPM2B; MALIN
• Summary: The protein encoded by this gene is a single subunit E3 ubiquitin ligase. Laforin is polyubiquitinated by the encoded protein. Defects in this intronless gene lead to an accumulation of laforin and onset of Lafora disease, also known as progressive myoclonic epilepsy type 2 (EPM2).[provided by RefSeq, Mar 2010]