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Human METRNL activation kit by CRISPRa

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SKU
GA117106
METRNL CRISPRa kit - CRISPR gene activation of human meteorin like, glial cell differentiation regulator
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA334847 Rabbit Polyclonal Anti-METRNL Antibody
100 ul
$585.00
RC210299 METRNL (Myc-DDK-tagged)-Human meteorin, glial cell differentiation regulator-like (METRNL)
10 ug
$450.00

Other products for "METRNL"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol METRNL
Locus ID 284207
Components

GA117106G1, METRNL gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA117106G2, METRNL gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA117106G3, METRNL gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_001004431, NM_001363853
UniProt ID Q641Q3
Synonyms MGC99788
Summary Hormone induced following exercise or cold exposure that promotes energy expenditure. Induced either in the skeletal muscle after exercise or in adipose tissue following cold exposure and is present in the circulation. Able to stimulate energy expenditure associated with the browning of the white fat depots and improves glucose tolerance. Does not promote an increase in a thermogenic gene program via direct action on adipocytes, but acts by stimulating several immune cell subtypes to enter the adipose tissue and activate their prothermogenic actions. Stimulates an eosinophil-dependent increase in IL4 expression and promotes alternative activation of adipose tissue macrophages, which are required for the increased expression of the thermogenic and anti-inflammatory gene programs in fat. Required for some cold-induced thermogenic responses, suggesting a role in metabolic adaptations to cold temperatures (By similarity).UniProtKB/Swiss-Prot Function
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Documents
Resources
Other Versions
SKU Description Size Price
KN410299 METRNL - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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