Human MED19 activation kit by CRISPRa

SKU GA116500

MED19 CRISPRa kit - CRISPR gene activation of human mediator complex subunit 19

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: MED19
• Locus ID: 219541
• Components:

  GA116500G1, MED19 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA116500G2, MED19 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA116500G3, MED19 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001317078, NM_153450, NR_157587
• UniProt ID: A0JLT2
• Synonyms: DT2P1G7; LCMR1; MED19AS
• Summary: The protein encoded by this gene is a subunit of the Mediator complex, which binds to gene-specific regulatory factors and provides support for the basal RNA polymerase II transcription machinery. This gene has been implicated in the growth of several types of cancer, and inhibition of its expression inhibits the growth and spread of these cancers. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]