Human MUC20 activation kit by CRISPRa

SKU GA116372

MUC20 CRISPRa kit - CRISPR gene activation of human mucin 20, cell surface associated

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: MUC20
• Locus ID: 200958
• Components:

  GA116372G1, MUC20 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA116372G2, MUC20 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA116372G3, MUC20 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001098516, NM_001282506, NM_001291833, NM_020790, NM_152673
• UniProt ID: Q8N307
• Synonyms: MUC-20
• Summary: This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins secreted by many epithelial tissues to form an insoluble mucous barrier. The C-terminus of this family member associates with the multifunctional docking site of the MET proto-oncogene and suppresses activation of some downstream MET signaling cascades. The protein features a mucin tandem repeat domain that varies between two and six copies in most individuals. Multiple variants encoding different isoforms have been found for this gene. A related pseudogene, which is also located on chromosome 3, has been identified. [provided by RefSeq, Apr 2014]