Human TMEM201 activation kit by CRISPRa

SKU GA116324

TMEM201 CRISPRa kit - CRISPR gene activation of human transmembrane protein 201

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: TMEM201
• Locus ID: 199953
• Components:

  GA116324G1, TMEM201 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA116324G2, TMEM201 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA116324G3, TMEM201 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001010866, NM_001130924
• UniProt ID: Q5SNT2
• Synonyms: Ima1; NET5; SAMP1
• Summary: Involved in nuclear movement during fibroblast polarization and migration. Proposed to be involved in actin-dependent nuclear movement via association with transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow (By similarity). Overexpression can recruit Ran GTPase to the nuclear periphery (PubMed:27541860).[UniProtKB/Swiss-Prot Function]