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Human TMEM64 activation kit by CRISPRa

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SKU
GA116184
TMEM64 CRISPRa kit - CRISPR gene activation of human transmembrane protein 64
  $1,657.00
4 Weeks*

Frequently Bought Together (1)

RC228256L3V Lenti ORF particles, TMEM64 (Myc-DDK tagged) - Human transmembrane protein 64 (TMEM64), transcript variant 2, 200ul, >10^7 TU/mL
200 ul
$850.00

Other products for "TMEM64"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol TMEM64
Locus ID 169200
Components

GA116184G1, TMEM64 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA116184G2, TMEM64 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA116184G3, TMEM64 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_001008495, NM_001146273
UniProt ID Q6YI46
Synonyms DKFZp762C1112
Summary Positively regulates TNFSF11-induced osteoclast differentiation. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with SERCA2 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca (2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca (2+) signaling cascades that promote osteoclast differentiation and activation. Negatively regulates osteoblast differentiation and positively regulates adipocyte differentiation via modulation of the canonical Wnt signaling pathway. Mediates the switch in lineage commitment to osteogenesis rather than to adipogenesis in mesenchymal stem cells by negatively regulating the expression, activity and nuclear localization of CTNNB1.UniProtKB/Swiss-Prot Function
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Documents
Resources
Other Versions
SKU Description Size Price
KN419803 TMEM64 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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