Human BHLHA15 activation kit by CRISPRa

SKU GA116177

BHLHA15 CRISPRa kit - CRISPR gene activation of human basic helix-loop-helix family member a15

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: BHLHA15
• Locus ID: 168620
• Components:

  GA116177G1, BHLHA15 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA116177G2, BHLHA15 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA116177G3, BHLHA15 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_177455
• UniProt ID: Q7RTS1
• Synonyms: BHLHB8; MIST1
• Summary: Plays a role in controlling the transcriptional activity of MYOD1, ensuring that expanding myoblast populations remain undifferentiated. Repression may occur through muscle-specific E-box occupancy by homodimers. May also negatively regulate bHLH-mediated transcription through an N-terminal repressor domain. Serves as a key regulator of acinar cell function, stability, and identity. Also required for normal organelle localization in exocrine cells and for mitochondrial calcium ion transport. May function as a unique regulator of gene expression in several different embryonic and postnatal cell lineages. Binds to the E-box consensus sequence 5'-CANNTG-3' (By similarity).[UniProtKB/Swiss-Prot Function]