Human OTUD7A activation kit by CRISPRa

SKU GA116030

OTUD7A CRISPRa kit - CRISPR gene activation of human OTU deubiquitinase 7A

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: OTUD7A
• Locus ID: 161725
• Components:

  GA116030G1, OTUD7A gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA116030G2, OTUD7A gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA116030G3, OTUD7A gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001329907, NM_130901
• UniProt ID: Q8TE49
• Synonyms: C15orf16; C16ORF15; CEZANNE2; OTUD7
• Summary: The protein encoded by this gene is a deubiquitinizing enzyme and possible tumor suppressor. The encoded protein acts on TNF receptor associated factor 6 (TRAF6) to control nuclear factor kappa B expression. However, this gene is downregulated by SNAIL1 in hepatocellular carcinoma cells, contributing to their progression and malignancy. [provided by RefSeq, Aug 2016]