Human ZNF420 activation kit by CRISPRa

SKU GA115639

ZNF420 CRISPRa kit - CRISPR gene activation of human zinc finger protein 420

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: ZNF420
• Locus ID: 147923
• Components:

  GA115639G1, ZNF420 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA115639G2, ZNF420 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA115639G3, ZNF420 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_144689, NM_001329515, NM_001329516, NM_001329517, NM_001329518, NM_001329519, NM_001329520, NM_001329521, NM_001329522, NM_001329524, NR_138039
• UniProt ID: Q8TAQ5
• Synonyms: APAK
• Summary: The protein encoded by this gene is a KRAB-type zinc finger protein that negatively-regulates p53-mediated apoptosis. Under stress conditions, the encoded protein is phosphorylated by ATM and dissociates from p53, which activates p53 and initiates apoptosis. [provided by RefSeq, Jul 2016]