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Human KICS2 activation kit by CRISPRa

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SKU
GA115503
C12orf66 CRISPRa kit - CRISPR gene activation of human chromosome 12 open reading frame 66
  $1,657.00
4 Weeks*

Frequently Bought Together (1)

RC209906 C12orf66 (Myc-DDK-tagged)-Human chromosome 12 open reading frame 66 (C12orf66)
10 ug
$457.00

Other products for "KICS2"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol KICS2
Locus ID 144577
Components

GA115503G1, KICS2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA115503G2, KICS2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA115503G3, KICS2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Shipping Ambient
Reference Data
RefSeq NM_001300940, NM_001300941, NM_152440
UniProt ID Q96MD2
Summary As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose.UniProtKB/Swiss-Prot Function
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Documents
Resources
Other Versions
SKU Description Size Price
KN409906 C12orf66 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

file-alt Citations

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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