Human EVC2 activation kit by CRISPRa

SKU GA115186

EVC2 CRISPRa kit - CRISPR gene activation of human EvC ciliary complex subunit 2

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: EVC2
• Locus ID: 132884
• Components:

  GA115186G1, EVC2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA115186G2, EVC2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA115186G3, EVC2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001166136, NM_147127
• UniProt ID: Q86UK5
• Synonyms: LBN; WAD
• Summary: This gene encodes a protein that functions in bone formation and skeletal development. Mutations in this gene, as well as in a neighboring gene that lies in a head-to-head configuration, cause Ellis-van Creveld syndrome, an autosomal recessive skeletal dysplasia that is also known as chondroectodermal dysplasia. Mutations in this gene also cause acrofacial dysostosis Weyers type, also referred to as Curry-Hall syndrome, a disease that combines limb and facial abnormalities. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]