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Human RFFL activation kit by CRISPRa

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SKU
GA114651
RFFL CRISPRa kit - CRISPR gene activation of human ring finger and FYVE like domain containing E3 ubiquitin protein ligase
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA350343 Rabbit Polyclonal Anti-RFFL Antibody
100 ul
$205.00
RC212645 RFFL (Myc-DDK-tagged)-Human ring finger and FYVE-like domain containing 1 (RFFL), transcript variant 1
10 ug
$457.00

Other products for "RFFL"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol RFFL
Locus ID 117584
Components

GA114651G1, RFFL gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA114651G2, RFFL gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA114651G3, RFFL gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_001017368, NM_057178, NR_037713
UniProt ID Q8WZ73
Synonyms CARP-2; CARP2; FRING; RIFIFYLIN; RNF34L; RNF189
Summary E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Mediates 'Lys-48'-linked polyubiquitination of PRR5L and its subsequent proteasomal degradation thereby indirectly regulating cell migration through the mTORC2 complex. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis. Negatively regulates the tumor necrosis factor-mediated signaling pathway through targeting of RIPK1 to ubiquitin-mediated proteasomal degradation. Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation. Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN. May also play a role in endocytic recycling.UniProtKB/Swiss-Prot Function
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Documents
Resources
Other Versions
SKU Description Size Price
KN412645 RFFL - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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