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Human NLRP3 activation kit by CRISPRa

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SKU
GA114436
NLRP3 CRISPRa kit - CRISPR gene activation of human NLR family pyrin domain containing 3
  $1,657.00
4 Weeks*

Frequently Bought Together (1)

RC220952 NLRP3 (Myc-DDK-tagged)-Human NLR family, pyrin domain containing 3 (NLRP3), transcript variant 1
10 ug
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Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol NLRP3
Locus ID 114548
Components

GA114436G1, NLRP3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA114436G2, NLRP3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA114436G3, NLRP3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_001079821, NM_001127461, NM_001127462, NM_001243133, NM_004895, NM_183395
UniProt ID Q96P20
Synonyms AGTAVPRL; AII; AVP; C1orf7; CIAS1; CLR1.1; FCAS; FCAS1; FCU; MWS; NALP3; PYPAF1
Summary This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NLRP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. The SARS-CoV 3a protein, a transmembrane pore-forming viroporin, has been shown to activate the NLRP3 inflammasome via the formation of ion channels in macrophages. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, neonatal-onset multisystem inflammatory disease (NOMID), keratoendotheliitis fugax hereditarian, and deafness, autosomal dominant 34, with or without inflammation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid. provided by RefSeq, Aug 2020
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Documents
Resources
Other Versions
SKU Description Size Price
KN213623 NLRP3 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN213623BN NLRP3 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN213623LP NLRP3 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN213623RB NLRP3 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN413623 NLRP3 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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