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Human TMEM106A activation kit by CRISPRa

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SKU
GA114401
TMEM106A CRISPRa kit - CRISPR gene activation of human transmembrane protein 106A
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA320083 Rabbit Polyclonal TMEM106A Antibody
100 ug
$640.00
RC237011 TMEM106A (myc-DDK-tagged) - Human transmembrane protein 106A (TMEM106A), transcript variant 1
10 ug
$289.00 $300.00

Other products for "TMEM106A"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol TMEM106A
Locus ID 113277
Components

GA114401G1, TMEM106A gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA114401G2, TMEM106A gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA114401G3, TMEM106A gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Shipping Ambient
Reference Data
RefSeq NM_001291586, NM_001291587, NM_001291588, NM_145041
UniProt ID Q96A25
Summary Activates macrophages and polarizes them into M1-like macrophages through the activation of the MAPK and NF-kappaB signaling pathway. Upon activation, upregulates the expression of CD80, CD86, CD69 and MHC II on macrophages, and induces the release of pro-inflammatory cytokines such as TNF, IL1B, IL6, CCL2 and nitric oxide (By similarity). May play a role in inhibition of proliferation and migration (PubMed:30456879, PubMed:29131025).UniProtKB/Swiss-Prot Function
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Documents
Resources
Other Versions
SKU Description Size Price
KN423763 TMEM106A - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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