Human FNIP1 activation kit by CRISPRa

SKU GA114346

FNIP1 CRISPRa kit - CRISPR gene activation of human folliculin interacting protein 1

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: FNIP1
• Locus ID: 96459
• Components:

  GA114346G1, FNIP1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA114346G2, FNIP1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA114346G3, FNIP1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001008738, NM_133372, NM_001346113, NM_001346114
• UniProt ID: Q8TF40
• Synonyms: DKFZp686E18167; DKFZp781P0215; KIAA1961; MGC667
• Summary: This gene encodes a protein that binds to the tumor suppressor protein folliculin and to AMP-activated protein kinase (AMPK). The encoded protein participates in the regulation of cellular metabolism and nutrient sensing by modulating the AMPK and target of rapamycin signaling pathways. This gene has a closely related paralog that encodes a protein with similar binding activities. Both related proteins also associate with the molecular chaperone heat shock protein-90 (Hsp90) and negatively regulate its ATPase activity and facilitate its association with folliculin. [provided by RefSeq, Jul 2017]