Human CAMK2N2 activation kit by CRISPRa

SKU GA114319

CAMK2N2 CRISPRa kit - CRISPR gene activation of human calcium/calmodulin dependent protein kinase II inhibitor 2

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: CAMK2N2
• Locus ID: 94032
• Components:

  GA114319G1, CAMK2N2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA114319G2, CAMK2N2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA114319G3, CAMK2N2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_033259
• UniProt ID: Q96S95
• Synonyms: CAM-KIIN; CAMKIIN
• Summary: This gene encodes a protein that is highly similar to the rat CaM-KII inhibitory protein, an inhibitor of calcium/calmodulin-dependent protein kinase II (CAMKII). CAMKII regulates numerous physiological functions, including neuronal synaptic plasticity through the phosphorylation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate (AMPA) receptors. Studies of the similar protein in rat suggest that this protein may function as a negative regulator of CaM-KII and may act to inhibit the phosphorylation of AMPA receptors. [provided by RefSeq, Jul 2008]