Human NAPRT1 (NAPRT) activation kit by CRISPRa

SKU GA114263

NAPRT CRISPRa kit - CRISPR gene activation of human nicotinate phosphoribosyltransferase

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: NAPRT
• Locus ID: 93100
• Components:

  GA114263G1, NAPRT1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA114263G2, NAPRT1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA114263G3, NAPRT1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001286829, NM_145201, NM_001363146, NM_001363145
• UniProt ID: Q6XQN6
• Synonyms: NAPRT1; PP3856
• Summary: Nicotinic acid (NA; niacin) is converted by nicotinic acid phosphoribosyltransferase (NAPRT; EC 2.4.2.11) to NA mononucleotide (NaMN), which is then converted to NA adenine dinucleotide (NaAD), and finally to nicotinamide adenine dinucleotide (NAD), which serves as a coenzyme in cellular redox reactions and is an essential component of a variety of processes in cellular metabolism including response to stress (Hara et al., 2007).[supplied by OMIM, Mar 2008]