Human NAF1 activation kit by CRISPRa

SKU GA114209

NAF1 CRISPRa kit - CRISPR gene activation of human nuclear assembly factor 1 ribonucleoprotein

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: NAF1
• Locus ID: 92345
• Components:

  GA114209G1, NAF1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA114209G2, NAF1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA114209G3, NAF1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001128931, NM_138386
• UniProt ID: Q96HR8
• Synonyms: nuclear assembly factor 1 homolog; nuclear assembly factor 1 homolog (S. cerevisiae)
• Summary: RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis. During assembly of the H/ACA snoRNPs complex, it associates with the complex and disappears during maturation of the complex and is replaced by NOLA1/GAR1 to yield mature H/ACA snoRNPs complex. Probably competes with NOLA1/GAR1 for binding with DKC1/NOLA4.[UniProtKB/Swiss-Prot Function]