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Human TRAF4AF1 (KNSTRN) activation kit by CRISPRa

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SKU
GA114019
KNSTRN CRISPRa kit - CRISPR gene activation of human kinetochore localized astrin (SPAG5) binding protein
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA333584 Rabbit Polyclonal Anti-KNSTRN Antibody
100 ul
$585.00
RC222981 KNSTRN (Myc-DDK-tagged)-Human chromosome 15 open reading frame 23 (C15orf23), transcript variant 1
10 ug
$300.00

Other products for "KNSTRN"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol KNSTRN
Locus ID 90417
Components

GA114019G1, TRAF4AF1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA114019G2, TRAF4AF1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA114019G3, TRAF4AF1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Shipping Ambient
Reference Data
RefSeq NM_001142761, NM_001142762, NM_033286
UniProt ID Q9Y448
Synonyms C15orf23; HSD11; SKAP; TRAF4AF1
Summary Essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase (PubMed:19667759). Promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:19667759, PubMed:22110139). The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments (PubMed:21402792). Required for kinetochore oscillations and dynamics of microtubule plus-ends during live cell mitosis, possibly by forming a link between spindle microtubule plus-ends and mitotic chromosomes to achieve faithful cell division (PubMed:23035123). May be involved in UV-induced apoptosis via its interaction with PRPF19; however, these results need additional evidences (PubMed:24718257).UniProtKB/Swiss-Prot Function
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Documents
Resources
Other Versions
SKU Description Size Price
KN422981 KNSTRN - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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