Human ATG4D activation kit by CRISPRa

SKU GA113811

ATG4D CRISPRa kit - CRISPR gene activation of human autophagy related 4D cysteine peptidase

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: ATG4D
• Locus ID: 84971
• Components:

  GA113811G1, ATG4D gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA113811G2, ATG4D gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA113811G3, ATG4D gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001281504, NM_032885, NR_104024, NR_104025
• UniProt ID: Q86TL0
• Synonyms: APG4-D; APG4D; AUTL4
• Summary: Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene belongs to the autophagy-related protein 4 (Atg4) family of C54 endopeptidases. Members of this family encode proteins that play a role in the biogenesis of autophagosomes, which sequester the cytosol and organelles for degradation by lysosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]