Human NFATC2IP activation kit by CRISPRa

SKU GA113753

NFATC2IP CRISPRa kit - CRISPR gene activation of human nuclear factor of activated T cells 2 interacting protein

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: NFATC2IP
• Locus ID: 84901
• Components:

  GA113753G1, NFATC2IP gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA113753G2, NFATC2IP gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA113753G3, NFATC2IP gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_032815
• UniProt ID: Q8NCF5
• Synonyms: ESC2; NIP45; RAD60
• Summary: In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity). Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity).[UniProtKB/Swiss-Prot Function]