Human QRX (RAX2) activation kit by CRISPRa

SKU GA113714

RAX2 CRISPRa kit - CRISPR gene activation of human retina and anterior neural fold homeobox 2

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: RAX2
• Locus ID: 84839
• Components:

  GA113714G1, QRX gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA113714G2, QRX gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA113714G3, QRX gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001319074, NM_032753
• UniProt ID: Q96IS3
• Synonyms: ARMD6; CORD11; QRX; RAXL1
• Summary: This gene encodes a homeodomain-containing protein that plays a role in eye development. Mutation of this gene causes age-related macular degeneration type 6, an eye disorder resulting in accumulations of protein and lipid beneath the retinal pigment epithelium and within the Bruch's membrane. Defects in this gene can also cause cone-rod dystrophy type 11, a disease characterized by the initial degeneration of cone photoreceptor cells and resulting in loss of color vision and visual acuity, followed by the degeneration of rod photoreceptor cells, which progresses to night blindness and the loss of peripheral vision. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]