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Human ALKBH7 activation kit by CRISPRa

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SKU
GA113463
ALKBH7 CRISPRa kit - CRISPR gene activation of human alkB homolog 7
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA373465 ALKBH7 Rabbit polyclonal Antibody
100 ul
$410.00
RC202583 ALKBH7 (Myc-DDK-tagged)-Human alkB, alkylation repair homolog 7 (E. coli) (ALKBH7)
10 ug
$300.00

Other products for "ALKBH7"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol ALKBH7
Locus ID 84266
Components

GA113463G1, ALKBH7 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA113463G2, ALKBH7 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA113463G3, ALKBH7 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_032306
UniProt ID Q9BT30
Synonyms ABH7; SPATA11; UNQ6002
Summary May function as protein hydroxylase; can catalyze auto-hydroxylation at Leu-110 (in vitro), but this activity may be due to the absence of the true substrate (PubMed:25122757). Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death (PubMed:23666923). ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage (PubMed:23666923). Does not display DNA demethylase activity (PubMed:23666923). Involved in fatty acid metabolism (By similarity).UniProtKB/Swiss-Prot Function
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Documents
Resources
Other Versions
SKU Description Size Price
KN402583 ALKBH7 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

file-alt Citations

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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