Human RHNO1 activation kit by CRISPRa
Specifications
| Product Data | |
| Format | 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug) |
|---|---|
| Target Symbol | RHNO1 |
| Locus ID | 83695 |
| Components |
GA113237G1, RHNO1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA113237G2, RHNO1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA113237G3, RHNO1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077 |
| OTI Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_001252499, NM_001252500, NM_001257097, NM_001257098, NM_031465, NR_027363, NR_027364, NR_027365, NR_046432, NR_046433 |
| UniProt ID | Q9BSD3 |
| Synonyms | C12orf32; HKMT1188; RHINO |
| Summary | Plays a role in DNA damage response (DDR) signaling upon genotoxic stresses such as ionizing radiation (IR) during the S phase. Recruited to sites of DNA damage through interaction with the 9-1-1 cell-cycle checkpoint response complex and TOPBP1 in a ATR-dependent manner. Required for the progression of the G1 to S phase transition. Plays a role in the stimulation of CHEK1 phosphorylation.UniProtKB/Swiss-Prot Function |
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