Human NPL activation kit by CRISPRa

SKU GA113008

NPL CRISPRa kit - CRISPR gene activation of human N-acetylneuraminate pyruvate lyase

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: NPL
• Locus ID: 80896
• Components:

  GA113008G1, NPL gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA113008G2, NPL gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA113008G3, NPL gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001200050, NM_001200051, NM_001200052, NM_001200056, NM_030769
• UniProt ID: Q9BXD5
• Synonyms: C1orf13; C112; NAL; NPL1
• Summary: This gene encodes a member of the N-acetylneuraminate lyase sub-family of (beta/alpha)(8)-barrel enzymes. N-acetylneuraminate lyases regulate cellular concentrations of N-acetyl-neuraminic acid (sialic acid) by mediating the reversible conversion of sialic acid into N-acetylmannosamine and pyruvate. A pseudogene of this gene is located on the short arm of chromosome 2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]