Human EFHD1 activation kit by CRISPRa

SKU GA112905

EFHD1 CRISPRa kit - CRISPR gene activation of human EF-hand domain family member D1

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: EFHD1
• Locus ID: 80303
• Components:

  GA112905G1, EFHD1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA112905G2, EFHD1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA112905G3, EFHD1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001243252, NM_001308395, NM_025202, NR_027663
• UniProt ID: Q9BUP0
• Synonyms: MST133; MSTP133; PP3051; SWS2
• Summary: This gene encodes a member of the EF-hand super family of calcium binding proteins, which are involved in a variety of cellular processes including mitosis, synaptic transmission, and cytoskeletal rearrangement. The protein encoded by this gene is composed of an N-terminal disordered region, proline-rich elements, two EF-hands, and a C-terminal coiled-coil domain. This protein has been shown to associate with the mitochondrial inner membrane, and in HeLa cells, acts as a novel mitochondrial calcium ion sensor for mitochondrial flash activation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016]